Chemdraw Software Free Download For Windows 8 64 Bit
From EndNote - smartly advances research and publishing by organizing images with text, and by providing built-in Microsoft Word templates for a variety of journals. Long known for Bibliographies Made Easy, EndNote now defines Manuscripts Made Easy. EndNote allows you to organize more than just text. Any type of generic image (e.g., BMP, TIFF, JPEG) or application file (e.g., Microsoft Excel, PhotoShop, ChemDraw) can be managed along with your text references using the new image and caption fields in any reference type. Now you can apply keywords and search for nontextual data the same way you do for references.
Introduction The immense development of microelectronics has banished the use of a typing machine, drawing pen, Indian ink and templates. Instead, text editors like MS Word, Corel WordPerfect or Apache OpenOffice, etc. Are of general use today. With the aid of these one can create professional looking articles and drawings, and a large amount of time for the rewriting, redrawing and making corrections can be spared as well. The creation of chemical structures with the conventional drawing software applications would be extremely painstaking and practically impossible.
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With publication in mind aesthetics and quality come to the front, ensured by built-in templates, bonds constrained to fixed length and angles, etc. Direct 3D editing is usually not possible – 3D features of a molecule can be visualised only by using the wedged/hashed bond drawing methodology.
The availability of different tools (palette of fonts, arrows, lines and curves, arcs and other shapes or graphic primitives) is also of high importance. If precise 3D representation of the molecule is needed, its import from a modelling program or 3D data base is the most feasible arrangement, although the recent drawing packages usually contain a simple 2D → 3D converter module or add-in. The presented drawing software applications work on the Windows or McIntosh platforms, some under Linux as well.
Nowadays an obvious requirement is WYSIWYG ( What You See Is What You Get). Under the Windows OS most tasks (printing, screen and printer fonts, resolution or any other system wide parameter) are maintained by Windows itself and its set-up is the determining factor. Another important point is the user-friendliness of the program.
This means that the user interface of the program, which ensures the interactive two-way communication between the user and the machine, should be simple but effective. The information sharing with other programs, database applications must also be many-sided. WinPLT, ICM-Chemist, ChemPen, JChemPaint, BKChem, ChemicPen, ChemTool, ICEdit, SketchEI, TouchMol, (standalone drawing applications) JME Editor, WebME Molecular Editor, ChemWriter, ChemVector, JSDraw, Xemistry sketcher (applets) Chem4Word, TouchMol for Office (add-ins for MS Office) Although all of these software packages are stand-alone applications, they are members of integrated suites as well, and they serve as the input modules of other database and modelling software applications or full information management systems. The distinction between and ranking of the lead applications is not so straightforward anymore: while in the first version of this review (1998) only three programs were included (ChemWindow, ChemDraw and Isis/Draw) and there were considerable differences between them, the drawing modules of the recent programs are side by side. Although the official name is Accelrys Draw now, it is referred as Biovia Draw as well, a member of the Biovia Pipeline Pilot information systems and Electronic Laboratory Notebook.
Accelrys Draw is the incarnation of the old ISIS/Draw with a brand new and more user-friendly interface. However, in a few tools ISIS/Draw compatible mode can be activated. A few new features (concerning mainly database use) have been added, a few drawing tools have been refined while a few other ones are not supported anymore. It is an alternative input modul to its own and the Reaxys databases as well. Chem(Bio)Draw is integrated with the Chem(Bio)Office, E-Notebook and other data management applications ('Ensemble for Chemistry').
The drawing of biological objects have been developed lately as well as integration with databases (with Scifinder recently). Available as Windows or Mac version. Version 13 has more bugs than its predecessors, version 14 is better.
The ChemBioDraw for iPad is a considerably simplified version intended for basic molecular editing. 2c,d,e. ChemSketch is the input modul of ChemFolder and several other applications of the ACD suite. It has several modules, extensions, and add-ins concerning the calculation of physical-chemical properties, import, processing and databasing of spectra and chromatograms, naming of molecules, prediction of NMR spectra, etc. Available as Windows or as an older Linux version.
A new player in the field of chemical editors is ChemDoodle for Windows, Mac and Linux. It has everything necessary for creating publication quality chemical documents.
It is integrated with ChemDoodle Web Components and ChemDoodle Mobile (iOS and Android phones). Its architecture is somewhat different from those of the old-timers, it has a handful of very useful brand new tools, a few new question-of-taste ones and some less impeccable features as well. In addition to structure and document editing features it contains several tools (some of them called 'widgets') such as constitutional and physicochemical descriptors and properties, embedding, editing and simulation of spectra, etc. The main drawback of the previous versions that round-trip editing was a bit cumbersome in the Windows has been resolved.
SoftShell's old ChemWindow has melted into the KnowItAll application suite and has been split to DrawIt and ReportIt – separate molecular editor and general editor applications, the latter is to import objects such as structures and spectra, arrange them on the page, and add text, annotations, reaction arrows, orbitals or other graphical objects – when I refer to DrawIt later, it implies always ReportIt, too. The DrawIt modules of the ChemWindow and Academic editions are the same. There are no relevant news for the time being. The latest version of Chemistry 4-D Draw has not been developed for several years, its homepage contains obsolate informations. The commercial version of Chemistry 4-D Draw is integrated with its Chem4D database and nomenclature modules (depending on the purchased version).
Available as Windows or Mac version. Special mention must be made on MarvinSketch. This is an interesting and very dynamically developing Java-based multiplatform chemical editor for drawing structures, reactions and queries with excellent features for web applications.
First and foremost it is the input module of the JChem Base chemical information management system (and of many other ones such as Reaxys). Its general editing properties, support of other graphical objects and texts are not as polished and sophisticated as those in the above six applications – for the time being, it is not a publishing software, therefore no full comparison has been made. However, its chemical editing properties are very similar or even better in a few respects, especially the creation of query structures. The basic version contains several tools and plugins which are fully missing from the other applications or are available only by separately purchasing them.
Although MarvinSketch is discussed briefly and separately at the end of this review, it is referenced and compared at several points. The different extensions (add-ins, plug-ins, bundled programs) come with the purchased versions, sometimes can be freely downloaded, sometimes must be purchased separately, sometimes are available as an Internet-service - therefore before making decisions it is highly recommended to visit the homepages of these programs and to inform, what modules are currently included in the price of the program & version being considered. These are briefly reviewed in and of this review.
The database and similar functions of the programs are not considered in this review, but structure drawing capabilities and text functions have been probed in great details and aspects. As extended and detailed discussions of every features are not possible, the most important comparisons are summarised in. Bold text indicates features which have been considered clearly beneficial as compared to the other programs, while italizations point to weak points. Of course, we are aware of the subjectivity of such comparisons. On the other hand, only 10-20% of the users are advanced ones: those reading and studying the documentation in detail, trying everything, and knowing such handy tools or tricks, which are unknown to the 'everyday' user.
Installation The automatic installers of the programs support customised setup. As most of the programs comprise several optional modules, it is advisable to choose the custom setup mode and to select only the modules really necessary. All installation procedures were flawless except ChemBioOffice 13 Ultra: even selecting the custom setup mode, the appropriate dialog window was not initialised and the full package was installed (checked under Windows XP, Vista and 7/64 versions). This has been fixed in version 14. Every program has one or more specific, proprietary input/output file formats with unique file name extensions.
These associations are always entered into the Windows registry. Most programs are able to deal with several other file formats, too. During the setup process some programs are quite aggressive and change the file name associations set previously by others. Fortunately, none of the reviewed chemical softwares behave this way and most of them are polite enough to ask in a dialog box how to handle the foreign file types (if the other program is also installed in your PC, don't allow to alter the corresponding associations). A rule of thumb with every computer program that save your documents often!
This is true in the case of the reviewed programs, too. Although they are generally stable enough, ChemBioDraw suffers mostly from rare and unexpected crashes. File operations, data movement Beyond the basic file input and output operations, the export and import facilities to/from other applications are of high importance. For example, if one has to import a 3D structure from a modelling program or embed an illustration created by another drawing program.
Support of foreign chemical file formats (filters) There are two basic chemical file types: program-specific sketch files, which include all objects of the drawing, and molecule files or molfiles, used mainly by modelling and database programs, these contain only the description of the molecules. Not regarding its own proprietary file formats ( MDL SKC and MOL molfiles) Accelrys Draw has a narrow choice of export/import possibilities. Chemistry 4-D Draw accepts only MDL molfiles as well. MDL sketch files are supported by ChemBioDraw and ChemSketch, and vice versa, Accelrys Draw now supports the import of ChemBioDraw CDX files. ChemDoodle also supports the most important foreign sketch files.
However, be prepared for inaccuracies during the import: fine tuning of the imported sketches is usually necessary. Of course, the not mutually supported features or objects will not be imported. DrawIt often crashed when tried to open ChemBioDraw files. Textual input formats of biopolymer sequences (Fasta, HELM) are also supported by Accelrys Draw and ChemBioDraw Support of Web-related file formats are also included in the latest versions (CML in ChemSketch and XML in ChemBioDraw and ChemDoodle, UniProt XML in Accelrys Draw); for the time being, these formats are not of general use in case of sketches. To summarize, The winner is ChemDoodle, ChemBioDraw is also respected followed by ChemSketch and MarvinSketch. These applications contain the highest number of export/import filters (although in spite of intensive beta-testing not all of them are bug-free).
Support of own older file formats During the evolution of these applications the structures of their own proprietary file formats evolved as well. Therefore backward-compatibility is never granted. For the time being, mentioned must be made on the following backward-compatibility issues:.
DrawIt does not support the older CW2 format of its predecessor ChemWindow – not a serious drawback as this format has slowly died out. Accelrys Draw – As far as chemistry is concerned the backward-compatibility of ISIS/Draw created skc files is 100%. In the case of other graphical objects it is not fully compatible with its predecessor (most of the differences between ISIS Draw and Accelrys Draw are discussed in its Help).
Some cosmetic and restyling should be necessary when using old files. The old TGF file format is not supported anymore. (Not too important, although it might be useful in special cases). Therefore don't delete the oldie but goldie ISIS Draw. In ChemBioDraw 12 the handling of colours has been altered. Some surprises might happen in drawings using many colours (differently coloured shaded objects), or when pasting objects into other applications. For example, shaded or filled boxes behave differently.
Other small inconsistencies have been found, too, for example arrows and font sizes of drawings created with earlier versions changed when opening in ChemBioDraw 12-14. Therefore make some tests before updating big projects, such as hundreds of figures for text books, just in case. Personally, I still use ChemBioDraw 11 when handling old projects. No backward compatibility issues were experienced in the case of ChemSketch, 12-13 years old files of posters look flawless in the recent version.
Support of other graphical file types and embedded objects This mainly concerns ChemBioDraw, ChemSketch and DrawIt as these applications are suitable for creating big size posters containing a collection of several data types. If illustrations, charts, diagrams are to be imported from another application, instead of bitmap images (JPG, TIF, GIF, etc.) vector formats (Windows metafiles WMF or EMF, SVG, PDF) should be preferred: the former ones cannot be resized without considerable loss of quality, the images become blurry, pixelated.
In the recent versions the SVG (Scalable Vector Graphics), an XML-based file format is an open standard nowadays for browsers and web applications is also supported. The next table summarises the import possibilities of different files and clipboard objects into the programs. Support of different graphics and embedded objects. Import of OLE objects means that the image directly cannot be embedded, only from another application, like World or Photoshop, etc., via copying/pasting it to the chemical application.
Chemdraw Software Free Download For Windows 8 64 Bit
Another helpful add-on of ChemSketch, ChemBioDraw, ChemDoodle and MarvinSketch is the quick search for structures feature. Contrary to ChemDoodle, this feature is not available in the basic versions of ChemBioDraw and ChemSketch, because it depends on the search engine of the corresponding database programs. In ChemSketch it enables the users to search for chemical structures on their file system in different chemical sketch and molfile formats as well as PDF, MS Word, Excel and Powerpoint documents and ACD databases, using exact or substructure search. The content of the matched files can be inspected in the preview window and opened in ChemSketch or in the application which created the file. In the ChemOffice suite, ChemFinder for Office is a similar stand-alone utility capable of browsing MS Office documents with OLE objects and ISIS and ChemBioDraw files. For the time being, it is somewhat slower and not so reliable as that one in ChemSketch, for example ChemFinder for Office 11 and 12 produced different hit lists from the same set of test files (using the same preferences).
The Search widget in ChemDoodle looks for structures in all supported sketch and molecule files. The content of the matched files and structures can be inspected in the preview window and opened for editing. MarvinSketch has the Document to Structure input mode: it supports the grabbing and opening of embedded structures from common MS Office document formats in addition to PDF, XML, HTML and TXT. Other drawing operations The drawing of different lines, polygons, circles and arcs, curves, arrows, etc. Were also tested.
Of course, no advanced features of a professional general drawing program should be expected, but basic functions are available and these are usually enough to create, for example, simple diagrams or biochemical sketches. In this respect ChemBioDraw and ChemSketch are the best: they contain more graphical objects than the other programs, on the other hand, these can be filled with simple or shaded colours and/or patterns. It is odd that pattern-filled objects are not supported in ChemBioDraw anymore. The support of Bezier curves (to create free-form, irregular curves or shapes) is the best in ChemDoodle. Customizations of filling and colouring of different objects and their shadow are the most advanced in ChemDoodle. The last version of ChemDoodle has clearly outrun the two older applications.
With ChemSketch a shaded double DNA helix can be created in five minutes. However, the new BioDraw templates of ChemBioDraw make the creation of DNA even more easier. Different basic atomic orbitals are available in all programs (although in different quality). As mentioned earlier, in ChemBioDraw 12 the handling of colours was changed. This might cause problems in the back compatibility of drawings with many colors.
The shadowed rectangles, etc. Behave differently as well, and a white box with black shadow cannot be created even when trying to assemble it from two pieces. MarvinSketch contains a basic set of lines, (rounded) rectangles, polylines. Insert electron flow arrows would be a handy tool, unfortunately, it does not work in the tested version. The drawings of figure A were created with ChemBioDraw.
The daunorubicin – DNA complex is from a Protein Data Bank file (PDB308D): the extracted structure was positioned with a 3D modelling program, transferred to ChemBioDraw as molecule file and some final touches were added. The middle sketch was produced with ChemSketch. A powerful feature of ChemBioDraw is the BioDraw palettes and toolbar.
The BioDraw toolbar contains adjustable templates to draw enzymes, receptors, cell membranes, DNA, immunoglobulins, laboratory animals, etc. BioArt templates have been added to the latest ChemDoodle as well. If necessary, these ready-made objects can be passed between these three applications using the SVG or EMF vector formats.
A B C A powerful feature of ChemBioDraw is the BioDraw palettes and toolbar. The BioDraw toolbar contains adjustable templates to draw enzymes, receptors, cell membranes, DNA, immunoglobulins, laboratory animals, etc. BioArt templates have been added to the latest ChemDoodle as well.
If necessary, these ready-made objects can be passed between these three applications using the SVG or EMF vector formats. As for the rotations of different objects, ChemBioDraw and ChemDoodle are the most advanced: both chemical structures and caption texts can be freely rotated; the rotation of the atom labels is an option. ChemWindow and ChemSketch rotate only the caption text, but not the structural text and atom symbols. Accelrys Draw and Chemistry 4-D Draw are not able to rotate caption text at all. The rotation of chemical structures and other objects could be important in the case of full-page figures: sometimes the use of the landscape mode would be necessary, but 90° image rotation is not available in a less sophisticated text editor. ChemDoodle provides several bond strike styles (charcoal, wobble, etc.) to style the drawing for brochures, banners or presentations.
To summarize: ChemBioDraw, ChemSketch and ChemDoodle are about neck and neck. When creating complex drawings from the available graphical objects ChemSketch is perhaps a hair's breadth ahead.
ChemBioDraw has the adventage when assembling from templates. ChemDoodle is a strong competitor, in several details clearly better than the two other applications. The drawing of laboratory glassware or process flow diagrams is very handy in DrawIt: the library files contain a vast amount of drawings and chemical engineering symbols.
ChemSketch, ChemBioDraw and ChemDoodle also contain templates for glassware (right image); additional templates are downloadable. The glassware elements of ChemDoodle are the most customizable (optionally filled or not, alteration of colours, flipping, addition of tubing, etc.): A very useful feature in ChemBioDraw and ChemDoodle is the TLC plate tool, especially for the users of laboratory e-notebooks. It allows the user to create and depict easily TLC plates with origin line, solvent front, and one or more lanes.
The lanes can be populated with spots of different Rf, size, shape, or colour, and with option for automatic display of Rf values. A similar TLC tool is available in ChemSketch, too, as an installable extension, but compared to the direct graphical editing of the former two it is quite clumsy (data has to be entered into a dialog table).
A new gel electrophoresis tool has been added to ChemBioDraw 13. Restyling of the sketches: Another important feature is the possibility of the restyling of different drawing objects, for example the change of the appearance of arrows, the width of lines or bonds, margin width, font size and so on.
Current settings can be saved from all programs and recall and apply later. Especially useful are the predefined journal settings (or style sheets). These are very flexible in the recent versions of all applications but in Chemistry 4-D Draw. In Chemistry 4-D Draw only the parameters of a full object can be modified, but not part of the object. In the other applications there might be some properties that can be set only globally, though, for example the display of aromatic delocalized circles in Accelrys Draw.
The technical realisations are obviously different: for example in ChemSketch floating toolboxes are used, in ChemBioDraw right-click menus. An inherited weak point in ChemBioDraw is the apply of style sheets and restyling of objects. No problems when creating a new document by opening a style sheet. However, when reapplying a style sheet to an existing document or changing document settings, not all of the new parameters are consequently applied.
When drawings are copy/pasted between two documents with different settings, structural text is changed accordingly, but captions not always: odd font-size values might appear. Another bug in the latest versions of ChemBioDraw that on using the ' Apply object settings from current document' option on imported structures, a clean-up procedure is also applied and this might mess up already nicely polished structures (it may happen when merely copy/pasting sketches from one document into another one). Thirdly, if a structure is dowloaded and inserted into an existing document by using the ' Find structure from name at ChemACX' way the document settings (bond length, bond width, etc.) are changed without warning! Could stuck as a great surprise later. Therefore it is highly recommended to put such structures into a temporal document first and then to copy it into its final place.
Hopefully, these glitches will be fixed sometimes Quite serious and very annoying bug in Accelrys Draw that when globally restyling an older document (e.g. Changing bond width or turning aromatic circles on or off) positions of the objects are often messed up and all actual settings are re-applied (not only the changed one). In addition, this cannot be undone.